If associated with a high resolution optical sensor through which the nanoresonator can be non-invasively probed and manipulated, the hybrid system holds promise to act as an ultrasensitive force probe. From a practical point of view, due to their size, nanoresonators are extremely sensitive to external forces. The benefit of exploring hybrid systems is manifold. Such combinations belong in the category of so-called “hybrid nanomechanical systems” which constitutes a rapidly expanding field in modern quantum- and nanophysics. Summary "The chief endeavor of the project is to develop, investigate and exploit systems associating nanoscale mechanical resonators with single quantum objects. Magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) and are two well-established powerful and versatile tools that are extensively used in many fields of research, in clinics and in industry. This project will yield to a broadly applicable method revolutionizing analytical chemistry, drug discovery and medical diagnostics, and thereby will provide a powerful tool to solve challenges at the forefront of molecular and chemical sciences today. These goals require a leap forward with respect to today’s protocols, and we propose to achieve this through a combination of innovative sample formulations, new NMR methodology and advanced instrumentation. Notable applications in the fields of drug discovery, metabolomics and real-time metabolic imaging in living animals will be demonstrated.
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The proposed project aims to leverage these new advances through a series of new concepts i) to generate the highest possible hyperpolarization that can be transported in a persistent state, and ii) to demonstrate their use in magnetic resonance experiments with > 10’000 fold sensitivity enhancements, with the potential of revolutionizing the fields of MRI and NMR.īy physically separating the source of polarization from the substrate at a microscopic level, we will achieve polarized samples with lifetimes of days that can be stored and transported over long distances to MRI centers, hospitals and NMR laboratories. We have recently pioneered breakthrough approaches using dissolution dynamic nuclear polarization (d-DNP) for preparing nuclear spins in highly aligned states, and therefore boosting sensitivity in several proof-of-concept reports on model systems. Hyperpolarization (HP) in principle provides a solution to this limitation. Summary Magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) and are two well-established powerful and versatile tools that are extensively used in many fields of research, in clinics and in industry.ĭespite considerable efforts involving highly sophisticated instrumentation, these techniques suffer from low sensitivity, which keeps many of today’s most interesting problems in modern analytical sciences below the limits of MR detection. United Kingdom (2346) Apply United Kingdom filter.Switzerland (847) Apply Switzerland filter.Netherlands (1074) Apply Netherlands filter.Luxembourg (17) Apply Luxembourg filter.United Kingdom, Portugal (1) Apply United Kingdom, Portugal filter.United Kingdom, Germany (1) Apply United Kingdom, Germany filter.Switzerland, Sweden (1) Apply Switzerland, Sweden filter.Switzerland, Spain, Denmark (1) Apply Switzerland, Spain, Denmark filter.Italy, United Kingdom (1) Apply Italy, United Kingdom filter.Israel, Germany (1) Apply Israel, Germany filter.Germany, United Kingdom (1) Apply Germany, United Kingdom filter.France, United Kingdom, Norway, Germany (1) Apply France, United Kingdom, Norway, Germany filter.(SH) Social Sciences & Humanities (177) Apply (SH) Social Sciences & Humanities filter.(LS) Life Sciences (425) Apply (LS) Life Sciences filter.(PE) Physical Sciences & Engineering (678) Apply (PE) Physical Sciences & Engineering filter.